First seconds from Johnny Mnemonic (1995)
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https://en.wikipedia.org/wiki/The_White_Plague
1982
Before that, The Andromeda Strain
What killed the aliens in The Day the Earth Stood Still?
Smallpox blankets
Catapulting dead bodies over city walls. Poisoning wells.
Only the methods have changed.
What killed the lizardmen in A.C. Crispin's "V"?
The black shakes