I'd rather care about teeth I have so I don't learn vanity in my life and just stop caring due disposable nature of my body.
I would not mind be able to repair shit I break due being idiot, which I admittedly am, but I'd rather not mess with my stock settings.
Of course there is speculative part of "what if accident", but then, I need material to learn on and from experience, making mistakes and dealing with consequences is path to improve.
Reasonable, me, probably, too. At least to the moment I will get a full and complete documentation on every possible setting. But why make a taboo from it? Bad guys (? transgender inhumans?) don't care about your taboos and will do that in any case.
I need material to learn on and from experience, making mistakes and dealing with consequences is path to improve.
This. Older civilisation - more consequences to deal with. You will have to deal with consequences of gene editing usage. For now, you already have to deal with consequences of mRNA gene editing. And how you will fix it if you deny gene editing technology as whole?
It is not taboo for me. Let me expand a bit on what I tried to express. If I can comprehend what given process does, I can estimate by myself consequences and risk to reward ratio (if any). For example they come up with some new whatever radio or any EM based tech , say some scanning techniques (like MRI) . I have provable skillset to asses what I'm dealing with before I go for this process, without need to trust 3rd party.
Also I have a problem with trusting things like that tech for a reason. I have to assume authority or so called expert in something that may be determinal for my well-being. By doing so I unintentionally turn off drive to know it, because "there is some one doing this 4433 years and knows better". As result I'm building my understanding of reality on somebody's else word (possibly agenda).
You don't need authority or expert to trust. Really, there are no things in the world that sane person could not comprehend.
As for the discussed CRISPR technology there is nothing complex at all. Special proteine split DNA and compare one strand with provided short RNA If RNA is complement to splitted part of DNA this proteine cuts/change nucleotide/whatever at that position. It is some kind of text search function in programming. You have a word, you have a text, you search a word in a text, if found, do something with text at that position - replace a word, letter or delete something. Simple, isn't it, if you get rid of all that biomedical slang?
The problem with that extremely simple thing is that to do something sensible you have to know exactly what you want to change and what will be the result. And that is the problem.
Really, things are not complex too. DNA is a program. 3 pairs of nucleotides (codons) progam an aminoacid. Some codons program stop or start condition for reader. Proteins built from aminoacids, so sequence of codons from start to stop encode a protein. And so on. The problem is that nearly nobody really try to reverse engineer that programming language and system. Most just do random changes in the hope to get the needed result.
It is like some webmonkey, trying to get modern fancy web2.0 site at the deadline insert random pieces of code into some big project using Ctrl+V Ctrl+C (CRISPR) without any understanding how all that things work and what he is doing in the hope to get something that will look like needed website and will be paid by emplyer. Obviously, the result is awful for end user, but profitable for webmonkey and employer.
Sane programmer will study how computer works, how it execute code and what that code do, and then will change exactly what he need. But nobody do that. Evetually, there are no books "gene editing for beginners" or "complete apple DNA documentation".
That is the problem with gene editing, not your inability to understand how things work.
So happens you are talking to programmer.
Changing one line of code in such a complex mechanism as body... I went ahead of myself, changing ONE instruction, within line of code, of something as complex, is ULTIMATELY risky. Take Linux kernel. No, take windows, everybody is using this shit. If there is one programmer there that will risk one line of code, assuming cross references, differences in hardware system are running on, and all possible hardware events, response of drivers for devices relying on given code. Memory allocations, I can keep counting potential issues for long time. One team wrote pieces of graphic suite, other wrote directX, other is responsible for file system, boot record and what not. First and foremost I doubt there is one person there that can comprehend all the garbage of a code windows with whole package is. Second, it's just bad practice and if you plan on this kind of "patching" you plan ahead, encapsulate pieces of code you plan to modify, expand on or reuse, and you apply STEPS ahead, because at core you assume updates. I dont know many human engineers that worked on the code that my compiler build from apparently procedurally executed code, given to me from my parents.
Third and probably most important part is. If DNA is like a BOOK, then A,T,C,G sequences are WORDS, then like in grammar sequences of VERY specific words create sentences.
I find it naive to believe human can edit book that is 133 astronomic units long (by the Science lol, length of 1bp x number of BP per cell x number of cells in the body). Its very admirable to have faith in humanity, but I find it impossible to buy in gene editing yet. The day it will become as easy and natural like 1 and 1 makes 2 and children grasp it, SURE, but then we sre godlike so we don't care anymore anyways.
I'd rather care about teeth I have so I don't learn vanity in my life and just stop caring due disposable nature of my body.
I would not mind be able to repair shit I break due being idiot, which I admittedly am, but I'd rather not mess with my stock settings.
Of course there is speculative part of "what if accident", but then, I need material to learn on and from experience, making mistakes and dealing with consequences is path to improve.
Reasonable, me, probably, too. At least to the moment I will get a full and complete documentation on every possible setting. But why make a taboo from it? Bad guys (? transgender inhumans?) don't care about your taboos and will do that in any case.
This. Older civilisation - more consequences to deal with. You will have to deal with consequences of gene editing usage. For now, you already have to deal with consequences of mRNA gene editing. And how you will fix it if you deny gene editing technology as whole?
It is not taboo for me. Let me expand a bit on what I tried to express. If I can comprehend what given process does, I can estimate by myself consequences and risk to reward ratio (if any). For example they come up with some new whatever radio or any EM based tech , say some scanning techniques (like MRI) . I have provable skillset to asses what I'm dealing with before I go for this process, without need to trust 3rd party.
Also I have a problem with trusting things like that tech for a reason. I have to assume authority or so called expert in something that may be determinal for my well-being. By doing so I unintentionally turn off drive to know it, because "there is some one doing this 4433 years and knows better". As result I'm building my understanding of reality on somebody's else word (possibly agenda).
You don't need authority or expert to trust. Really, there are no things in the world that sane person could not comprehend.
As for the discussed CRISPR technology there is nothing complex at all. Special proteine split DNA and compare one strand with provided short RNA If RNA is complement to splitted part of DNA this proteine cuts/change nucleotide/whatever at that position. It is some kind of text search function in programming. You have a word, you have a text, you search a word in a text, if found, do something with text at that position - replace a word, letter or delete something. Simple, isn't it, if you get rid of all that biomedical slang?
The problem with that extremely simple thing is that to do something sensible you have to know exactly what you want to change and what will be the result. And that is the problem.
Really, things are not complex too. DNA is a program. 3 pairs of nucleotides (codons) progam an aminoacid. Some codons program stop or start condition for reader. Proteins built from aminoacids, so sequence of codons from start to stop encode a protein. And so on. The problem is that nearly nobody really try to reverse engineer that programming language and system. Most just do random changes in the hope to get the needed result.
It is like some webmonkey, trying to get modern fancy web2.0 site at the deadline insert random pieces of code into some big project using Ctrl+V Ctrl+C (CRISPR) without any understanding how all that things work and what he is doing in the hope to get something that will look like needed website and will be paid by emplyer. Obviously, the result is awful for end user, but profitable for webmonkey and employer.
Sane programmer will study how computer works, how it execute code and what that code do, and then will change exactly what he need. But nobody do that. Evetually, there are no books "gene editing for beginners" or "complete apple DNA documentation".
That is the problem with gene editing, not your inability to understand how things work.
So happens you are talking to programmer. Changing one line of code in such a complex mechanism as body... I went ahead of myself, changing ONE instruction, within line of code, of something as complex, is ULTIMATELY risky. Take Linux kernel. No, take windows, everybody is using this shit. If there is one programmer there that will risk one line of code, assuming cross references, differences in hardware system are running on, and all possible hardware events, response of drivers for devices relying on given code. Memory allocations, I can keep counting potential issues for long time. One team wrote pieces of graphic suite, other wrote directX, other is responsible for file system, boot record and what not. First and foremost I doubt there is one person there that can comprehend all the garbage of a code windows with whole package is. Second, it's just bad practice and if you plan on this kind of "patching" you plan ahead, encapsulate pieces of code you plan to modify, expand on or reuse, and you apply STEPS ahead, because at core you assume updates. I dont know many human engineers that worked on the code that my compiler build from apparently procedurally executed code, given to me from my parents. Third and probably most important part is. If DNA is like a BOOK, then A,T,C,G sequences are WORDS, then like in grammar sequences of VERY specific words create sentences. I find it naive to believe human can edit book that is 133 astronomic units long (by the Science lol, length of 1bp x number of BP per cell x number of cells in the body). Its very admirable to have faith in humanity, but I find it impossible to buy in gene editing yet. The day it will become as easy and natural like 1 and 1 makes 2 and children grasp it, SURE, but then we sre godlike so we don't care anymore anyways.