I'm going to devil's advocate against his position:
You're right, mRNA treatments are not traditional vaccines and work against repository infections in a novel way. We would not expect the same patterns of infection as with smallpox or mumps.
This paper suggests ADE does not occur in CoVs because it infects respiratory epithelium, not macrophages.
The mRNA data demonstrates efficacy. Of 44,486 evaluable participants (50% in each cohort), irrespective of prior SARS-CoV-2 infection, 81 COVID-19 cases were observed among vaccine and 873 among placebo recipients.
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I'll stop there. I'm not trying to personally argue against the venerable doctor - I am in agreement with him, but I am just constructing the sort of rebuttal he is up against by trying to use facts and logic.
The efficacy of the vaccines is skewed - for relative risk reduction you may have the 90-95% effectiveness they claim (and one could argue against that based on how they tracked efficacy - only 8 weeks were patients followed remember), however absolute risk reduction in sars-COV-2 is less then 1%.
I'm going to devil's advocate against his position:
You're right, mRNA treatments are not traditional vaccines and work against repository infections in a novel way. We would not expect the same patterns of infection as with smallpox or mumps.
This paper suggests ADE does not occur in CoVs because it infects respiratory epithelium, not macrophages.
The mRNA data demonstrates efficacy. Of 44,486 evaluable participants (50% in each cohort), irrespective of prior SARS-CoV-2 infection, 81 COVID-19 cases were observed among vaccine and 873 among placebo recipients.
--
I'll stop there. I'm not trying to personally argue against the venerable doctor - I am in agreement with him, but I am just constructing the sort of rebuttal he is up against by trying to use facts and logic.
The efficacy of the vaccines is skewed - for relative risk reduction you may have the 90-95% effectiveness they claim (and one could argue against that based on how they tracked efficacy - only 8 weeks were patients followed remember), however absolute risk reduction in sars-COV-2 is less then 1%.