Personally after more than 30 years of self-trialing, hundreds of nutrition textbooks (mainstream, alternative, holistic, functional, ayurvedic, historical, TCM), thousands of research papers and subscription to several biochemist & metabolism subscription services and hundreds of personal "trials" gone wrong later, I can summarize the following:
-Get your compounds 90-95% from real whole organic seasonal local foods you yourself make into foods, unless you are chronically sick
-Take into your individual biochemical, genetic and microbiotic variance - what works for some may not work for you (you will find this out, I guarantee you this)
When supplementing, always think in terms of systemic processes: A may increase B ,but it may rate-limit C or decrease D.
When supplementing, always think in terms of inverse U dose/response-benefit curves: zero input of an essential nutrient may be harmful, then it starts to give more benefit as you increase the dosage - then it peaks at the top of the inverse U, and then it's all downhill from where until you hit actual damage/risks from more
When supplementing think in terms of anabolic/catabolic, mTOR/AMPK cycles - every now and then take total breaks off supplementation, preferably fast (only water + electrolytes) for a while, to trigger autophagy, mitophagy and general body clean-up. Again, this may not apply to you if you have serious (auto)immune or wasting related disorders (again, individuality, individuality, individuality)
Now for a quick summary of some of the actual supplements and ranges you mentioned:
high levels of continuous NAC can downregulate the protective function of your leukocytes and eosinophils
IMHO, your tryptophan, glutamine and glycine are within safe levels, but in some case, I'd take even clearly more of glutamine up-to 5-10g (yes grams) (If it does NOT excite/make you nervous) and glycine 2x5g glycine (as this is a great buffer against glyphosate, the shit that it is impossible to avoid in the USA)
Your choice of NAC-is great
If your glutathione synthesis is for some reason rate-limited or impaired, I'd suggest trialing with either S-Acetyl L-Glutathione or liposomal forms of L-glutathione
Always take Vitamin C with additional bioflavonoids for improved synergic effects
D3, always take in fat soluble form, pref. in lanolin, skip the "Made in China" sources and at that level 15-25kIU always take with vitamin K complex (LEF Super K is decent), so you don't mess up the calcium transport
Vitamin As (multiple) can be overdosed, some people start to get issues with 5000IU doses, some earlier/later. If you go higher, always combine with Vit D3, Vit E (complex) and Vit K (see above)
Vit Bs can be messed up (esp. detox/methylation cycles) if taken separately. A safer way is to take coenzymated B-complex with all the B-vitamins in the right form (i.e. take Jarrow B-Right, or Country Life Coenzyme B-complex). Just 1/4th to 1/2 a dose of that is more than enough to most
Vitamin C, why so low? Yes ,some (older) studies say VitC plasma levels can be saturated with 500mg in a healthy normal weight adult, but esp. people with severe oxidative stress and/or pathogen attacks can benefit from higher amounts (esp. temporarily). I'd first test my bowel tolerance :take several grams in a single dose and see if your stools become loose. Back off the dose 1g at a time until no more loose stools. That is your current (changes depending on body load/inflammation/attacks/immune deficiency) body upper limit. Use that as a guidance. Personally I take 1g/day, because I have no kidney stones, no heochromatosis risk, but if I get any symptoms of coming down with something, I can go up as high as 12 000 mg (12 grams) a day, divided to 4 doses
Vitamin E - this is a complex. I have found out that high using natural form (A.C. Grace Unique E, at no more than 145 IU /161mg) seems to be the best bet. You can get additional effects from tocotrienols (for that use DeltaGold tocotrienols, taken separately from tocopherols mentioned previously). This can have profound effects in older (>65yrs) immuno-compromised. Literature says that for normal people (not chronically sick) taking more than 20 IU /d of mixed tocopherols (natural form) doesn't seem to help a lot, and higher doses can be dangerous. NEVER use synthetic (dl-alpha-tocopherol).
Multi-mineral with microminerals - yeah this is highly important. I've only found a couple that I like and even they are not ideal (AOR Ortho minerals and Blue Bonnet chelated minerals without Iron). Biopureus.com has an excellent fulvic/humic combo of 73 ionic minerals, but it gets way too expensive fast
I would defintely keep Ubiquinol in the stack, esp. if you are lacking in energy
50mg zinc without copper can really skew your mineral balance. For every 10-15mg of supplemental zinc, add 2mg of copper. Copper is also needed for energy metabolism and immunity
EGCG does not work well as a zinc ionophore, but quercetin does. Out of the current easily available ones, zinc ascorbate (not the same as taking ascorbic acid and zinc together). You can get Zinc Ascorbate from NOW Ascorbate Mineral-C, InterPlexus Zinc Plus, Source naturals Ultimate Ascorbate C. Additionally Pyrithione and hinokitiol would also work as zinc ionophores, but are not easily/widely available. Pyrithione you can get from Persian shalots in some amounts
Berberine kills of microbiota, be careful with that. Also Berberine is a powerful antidiabetic drug, with profound blood sugar lowering effects. If one has a crap diet (too much carbs/sugar/processed crap) it can work wonders. personally for me on a cyclical ketogenic diet, it crashed my blood sugar too low. The therapeutic dosage for adults is 900mg-2000mg/d in several doses (usually after meals due to gastric distress issues)
Thieves oil, this is top notch, I have my own mixture from essential oils as well. Can get expensive, but I rarely need to use it. When I have to use a mask (hate those), I spray inner and outer surface of the mask with my own concoction
BONUS!
For an acute respiratory infection, I suggest using an compressor nebulizer with NaCL solution with 0.1% (some people go up to 2%-3%, but that can be damaging!) of hydrogen peroxide. This just kills bacteria and viruses on contact. Most people with initial first 5 days after contagion of COVID-19 in their lungs have immediate clearing of symptoms within 1 day. Of course, it also works against other viruses.
I really commend you for you work, finding a solution for yourself and taking charge of your own health. That alone makes you a fucking Thor in my book.
Respect!
Caveat emptor - I don't know a lot, but I know enough to be dangerous.
Always test carefully on yourself, go easy first, when trying a new supplement regime. Listen to and honour your body.
"Little knowledge is a dangerous thing."
I commend you on your approach.
Personally after more than 30 years of self-trialing, hundreds of nutrition textbooks (mainstream, alternative, holistic, functional, ayurvedic, historical, TCM), thousands of research papers and subscription to several biochemist & metabolism subscription services and hundreds of personal "trials" gone wrong later, I can summarize the following:
-Get your compounds 90-95% from real whole organic seasonal local foods you yourself make into foods, unless you are chronically sick -Take into your individual biochemical, genetic and microbiotic variance - what works for some may not work for you (you will find this out, I guarantee you this)
Now for a quick summary of some of the actual supplements and ranges you mentioned:
high levels of continuous NAC can downregulate the protective function of your leukocytes and eosinophils
IMHO, your tryptophan, glutamine and glycine are within safe levels, but in some case, I'd take even clearly more of glutamine up-to 5-10g (yes grams) (If it does NOT excite/make you nervous) and glycine 2x5g glycine (as this is a great buffer against glyphosate, the shit that it is impossible to avoid in the USA)
Your choice of NAC-is great
If your glutathione synthesis is for some reason rate-limited or impaired, I'd suggest trialing with either S-Acetyl L-Glutathione or liposomal forms of L-glutathione
Always take Vitamin C with additional bioflavonoids for improved synergic effects
D3, always take in fat soluble form, pref. in lanolin, skip the "Made in China" sources and at that level 15-25kIU always take with vitamin K complex (LEF Super K is decent), so you don't mess up the calcium transport
Vitamin As (multiple) can be overdosed, some people start to get issues with 5000IU doses, some earlier/later. If you go higher, always combine with Vit D3, Vit E (complex) and Vit K (see above)
Vit Bs can be messed up (esp. detox/methylation cycles) if taken separately. A safer way is to take coenzymated B-complex with all the B-vitamins in the right form (i.e. take Jarrow B-Right, or Country Life Coenzyme B-complex). Just 1/4th to 1/2 a dose of that is more than enough to most
Vitamin C, why so low? Yes ,some (older) studies say VitC plasma levels can be saturated with 500mg in a healthy normal weight adult, but esp. people with severe oxidative stress and/or pathogen attacks can benefit from higher amounts (esp. temporarily). I'd first test my bowel tolerance :take several grams in a single dose and see if your stools become loose. Back off the dose 1g at a time until no more loose stools. That is your current (changes depending on body load/inflammation/attacks/immune deficiency) body upper limit. Use that as a guidance. Personally I take 1g/day, because I have no kidney stones, no heochromatosis risk, but if I get any symptoms of coming down with something, I can go up as high as 12 000 mg (12 grams) a day, divided to 4 doses
Vitamin E - this is a complex. I have found out that high using natural form (A.C. Grace Unique E, at no more than 145 IU /161mg) seems to be the best bet. You can get additional effects from tocotrienols (for that use DeltaGold tocotrienols, taken separately from tocopherols mentioned previously). This can have profound effects in older (>65yrs) immuno-compromised. Literature says that for normal people (not chronically sick) taking more than 20 IU /d of mixed tocopherols (natural form) doesn't seem to help a lot, and higher doses can be dangerous. NEVER use synthetic (dl-alpha-tocopherol).
Multi-mineral with microminerals - yeah this is highly important. I've only found a couple that I like and even they are not ideal (AOR Ortho minerals and Blue Bonnet chelated minerals without Iron). Biopureus.com has an excellent fulvic/humic combo of 73 ionic minerals, but it gets way too expensive fast
I would defintely keep Ubiquinol in the stack, esp. if you are lacking in energy
50mg zinc without copper can really skew your mineral balance. For every 10-15mg of supplemental zinc, add 2mg of copper. Copper is also needed for energy metabolism and immunity
EGCG does not work well as a zinc ionophore, but quercetin does. Out of the current easily available ones, zinc ascorbate (not the same as taking ascorbic acid and zinc together). You can get Zinc Ascorbate from NOW Ascorbate Mineral-C, InterPlexus Zinc Plus, Source naturals Ultimate Ascorbate C. Additionally Pyrithione and hinokitiol would also work as zinc ionophores, but are not easily/widely available. Pyrithione you can get from Persian shalots in some amounts
Berberine kills of microbiota, be careful with that. Also Berberine is a powerful antidiabetic drug, with profound blood sugar lowering effects. If one has a crap diet (too much carbs/sugar/processed crap) it can work wonders. personally for me on a cyclical ketogenic diet, it crashed my blood sugar too low. The therapeutic dosage for adults is 900mg-2000mg/d in several doses (usually after meals due to gastric distress issues)
Thieves oil, this is top notch, I have my own mixture from essential oils as well. Can get expensive, but I rarely need to use it. When I have to use a mask (hate those), I spray inner and outer surface of the mask with my own concoction
BONUS!
I really commend you for you work, finding a solution for yourself and taking charge of your own health. That alone makes you a fucking Thor in my book.
Respect!
Caveat emptor - I don't know a lot, but I know enough to be dangerous.
Always test carefully on yourself, go easy first, when trying a new supplement regime. Listen to and honour your body.