Potential health risks of mRNA-based vaccine therapy: A hypothesis
(pmc.ncbi.nlm.nih.gov)
Comments (6)
sorted by:
Abstract
Therapeutic applications of synthetic mRNA were proposed more than 30 years ago, and are currently the basis of one of the vaccine platforms used at a massive scale as part of the public health strategy to get COVID-19 under control. To date, there are no published studies on the biodistribution, cellular uptake, endosomal escape, translation rates, functional half-life and inactivation kinetics of synthetic mRNA, rates and duration of vaccine-induced antigen expression in different cell types. Furthermore, despite the assumption that there is no possibility of genomic integration of therapeutic synthetic mRNA, only one recent study has examined interactions between vaccine mRNA and the genome of transfected cells, and reported that an endogenous retrotransposon, LINE-1 is unsilenced following mRNA entry to the cell, leading to reverse transcription of full length vaccine mRNA sequences, and nuclear entry. This finding should be a major safety concern, given the possibility of synthetic mRNA-driven epigenetic and genomic modifications arising. We propose that in susceptible individuals, cytosolic clearance of nucleotide modified synthetic (nms-mRNAs) is impeded. Sustained presence of nms-mRNA in the cytoplasm deregulates and activates endogenous transposable elements (TEs), causing some of the mRNA copies to be reverse transcribed. The cytosolic accumulation of the nms-mRNA and the reverse transcribed cDNA molecules activates RNA and DNA sensory pathways. Their concurrent activation initiates a synchronized innate response against non-self nucleic acids, prompting type-I interferon and pro-inflammatory cytokine production which, if unregulated, leads to autoinflammatory and autoimmune conditions, while activated TEs increase the risk of insertional mutagenesis of the reverse transcribed molecules, which can disrupt coding regions, enhance the risk of mutations in tumour suppressor genes, and lead to sustained DNA damage. Susceptible individuals would then expectedly have an increased risk of DNA damage, chronic autoinflammation, autoimmunity and cancer. In light of the current mass administration of nms-mRNA vaccines, it is essential and urgent to fully understand the intracellular cascades initiated by cellular uptake of synthetic mRNA and the consequences of these molecular events.
Very nice. I reached the same conclusion half way through - cancer and massive immune dysregulation. This is a giant fuck up for virologists, cell biologists, and immunologists. These points are the most basic cell bio/biochem info that is taught in grad school. I remain astounded that there aren't more people speaking out and denouncing these unscientific projects. Once again, the love of money is the root of all evil.
Thanks for sharing. Glad God got me out of that field before I became implicated in their failures.
It really is mind boggling.. I wish I knew what to say, it's all a terrible mess. I think it goes into transhumanism stuff too.
What do you consider transhumanism? Integrating foreign or non human DNA sequences into one's nuclear DNA in vivo? I mean... that's basically what HIV does
Yeah I think that would qualify. There have been many small steps in this transhumanism direction, boiling frog type stuff maybe. They've normalized things that should never have been up for negotiation, I think.
It’s not a “vaccine”, it’s gene therapy and it leads to transhumanism and the separation of a human’s soul to God. Rudolf Steiner knew this over 100 years ago.