Yes. I have a friend who was experimenting with mushrooms and concentrations of it and was shaken to the core, having pro-longed hallucinations, hearing voices, feeling shocks through his body, voices in his head, high anxiety, paranoia, etc.

It's interesting if you need to be further convinced that there is a spiritual realm. Some people only believe in the carnal flesh and believe everything goes black when we die. Some might argue that it is all merely hallucination and no spiritual "awakening" occurs.

I know of someone else in real life who overdosed on hallucinogens that caused suicidal thoughts and he stabbed himself. Was many years of therapy afterwards and they had him on anti-depressants and a cocktail of pharmaceuticals which probably just add on to psychotic chaos

Hallucinogens can overwhelm you with feelings of joy, hope, sadness, fear, etc Why some cultures utilize shamans as guardians for the trip.