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Primate98 5 points ago +5 / -0

The news itself is like a spear thrust at the heart of the Medical-Industrial Complex, but it cannot be underestimated that it comes out of the University of Oxford.

If you've ever wondered where the "official narrative" comes from in any area of what was once called a "liberal education", it's Oxford. Specifically, Oxford University Press (OUP) is the black hole at the center of the galaxy of what passes for modern culture, and the dark rays emanating from it "enlighten" all corners of our world. Want to pollute your mind? Get a book from OUP.

That it's the home of the Rhodes Scholarship should surprise no one reading this, and ties us into so many misadventures. Oxford probably has more spooks than Langley, since they got started centuries before.

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MidnightToker 3 points ago +3 / -0

Not a single doctor will ask you what your diet, mental health, or activity level is. Those three factors will be at the root cause of a majority of issues. When you actually look into health, a doctor is the last person you should be talking to. All a doctor is good for these days is fitting you into a medical code and prescribing what ever medication goes along with it. Also getting you TFO out the office as quickly as possible so they can cram more people through. The sickest people I know all see doctors routinely.

I had severe allergies and was on weekly shots and medication for years. I cleaned up my diet and started walking outside for a few hours a day. I eat nothing processed and eat as close to the foods raw state as I can. My allergies are for the most part completely gone.

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axolotl_peyotl [S] 2 points ago +2 / -0

source

Less than 6 percent of medical drugs have high-quality evidence to support their benefits, according to a recent study by the University of Oxford.

The study found that, of the 1,567 eligible medications approved under the Cochrane Reviews from 2008 to 2021, more than 94 percent were not supported by high-quality evidence.

Cochrane Reviews is a leading international journal and database combining all available and relevant evidence about treatments and health care policies. It is often referenced in national and international health care guidelines, and is especially prominent in Europe.

Reviewing Cochrane Reviews’ 35 percent of research papers, researchers found less than half of the drugs approved from 2008 to 2021 had moderate to high-quality evidence. Further, harms were underreported, with around 37 percent of interventions found with harm and 8.1 percent had significant evidence of harm.

“It is particularly worrying that the harms of healthcare interventions are rarely quantified,” wrote Dr. Jeremy Howick, one of the co-authors of the study, in The Conversation.

“For a doctor or patient to decide whether to use a treatment, they need to know whether the benefits outweigh the harms. If the harms are inadequately measured, an ‘informed choice’ is not possible.”

According to Howick, the “cut-off” year was 2008, as that was when Cochrane Reviews incorporated a system called grading quality of evidence and strength of recommendations (GRADE) to assess the quality of evidence.

The GRADE system used by Cochrane, is a transparent framework for developing and presenting summaries of evidence and provides a systematic approach for making clinical practice recommendations.

It is a widely adopted tool for grading the quality of evidence and for making recommendations with over 100 organizations worldwide endorsing GRADE.

Although authors of the Oxford study speculated that the poor findings for drugs backed up by high-quality evidence may be because the sample studies were “unrepresentative” of the population, Howicks argued that it was unlikely given the strictness of Cochrane Reviews.

A 2020 U.S. study published in JAMA also indicated the problem of medications being approved without rigorous testing and causing harm. The study examined drugs approved by the Food and Drug Administration from 1983 to 2018 and found that whilst the number of novel biologics approved increased, the review period by the organization decreased.

The authors wrote in the study that, the FDA “increasingly accepted less data and more surrogate measures,” clinical measures that show a correlation but may not necessarily guarantee a relationship.

Dr. David Light from Harvard University argued that currently, 80 percent of drugs being prescribed that are known to work are still generic drugs, with experienced physicians recommending to not take new drugs for at least five years.

Light wrote in his 2014 article that the majority of newly approved drugs bring little to no improvements, with 1 in 5 new prescriptions causing severe adverse events. At the same time, pharmaceutical prices for new drugs have soared with drug median release prices growing 85 times higher from 2008 to 2022.

“Potential harms should be measured with the same rigor as potential benefits,” concluded Howick. “The evidence-based medicine community is correct to continue calling for higher-quality research, and also justified in their skepticism that high-quality evidence for medical treatments is common or even improving.”

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tearsintherain 1 point ago +1 / -0

Damn sci-hub isn't fetching.