"Efficient Reverse Genetic Systems for Rapid Genetic Manipulation of Emergent and Preemergent Infectious Coronaviruses" - Adam S. Cockrell, Anne Beall, Boyd Yount, Ralph Baric
"In 2013 preemergent SARS-like CoVs were identified in horseshoe bats and found to be poised for entry into the human population [15] (Fig. 1). Importantly, much of the HCoV research over the last 15 years has been possible because of the capacity to generate infectious clones using highly efficient reverse genetics platforms [16], coupled with robust small animal models of human disease"
"Efficient Reverse Genetic Systems for Rapid Genetic Manipulation of Emergent and Preemergent Infectious Coronaviruses" - Adam S. Cockrell, Anne Beall, Boyd Yount, Ralph Baric
"In 2013 preemergent SARS-like CoVs were identified in horseshoe bats and found to be poised for entry into the human population [15] (Fig. 1). Importantly, much of the HCoV research over the last 15 years has been possible because of the capacity to generate infectious clones using highly efficient reverse genetics platforms [16], coupled with robust small animal models of human disease"
https://link.springer.com/protocol/10.1007/978-1-4939-6964-7_5
https://media.springernature.com/original/springer-static/image/chp%3A10.1007%2F978-1-4939-6964-7_5/MediaObjects/320534_1_En_5_Fig1_HTML.gif
https://media.springernature.com/original/springer-static/image/chp%3A10.1007%2F978-1-4939-6964-7_5/MediaObjects/320534_1_En_5_Fig2b_HTML.gif
Original Submission.
Archives: https://files.catbox.moe/8p1wwe.pdf
https://archive.is/FWHxG