Proably saving a few lives by not using the aerosol. But its kinda silly to use aerosol's anyway since they do eat up the ozone, and we do kinda need that.
But again, shocked me to find out they still use refrigerant in those ventolin brand puffers.
VENTOLIN HFA is a pressurized metered-dose aerosol unit fitted with a counter. VENTOLIN HFA is intended for oral inhalation only. Each unit contains a microcrystalline suspension of albuterol sulfate in propellant HFA-134a (1,1,1,2-tetrafluoroethane). It contains no other excipients.
R-134a and HFC-134a share the same chemical formula, C2H2F4, however, they have slightly different molecular structures. In contrast to R-134a, which is a chlorofluorocarbon (CFC), HFC-134a is a hydrofluorocarbon (HFC). The main difference is that CFCs include chlorine, which contributes to ozone depletion.
They still have this cardiac sensitizing potential though.
Five minutes later, they were exposed to the test substance for a total of approximately 10 minutes. After the first five minutes of exposure, each dog received a challenge injection of epinephrine. During the next five minutes of exposure, the dogs were monitored for the development of a cardiac arrhythmia. There were no arrhythmias at 75,000 ppm, and two of the 6 dogs displayed multifocal ventricular ectopic activity lasting approximately 2 seconds followed by several ectopic beats at 100,000 ppm. Under the conditions of this study, the no-observed-adverseeffect level (NOAEL) for cardiac sensitization was 75,000 ppm and the lowest-observed-adverse-effect level (LOAEL) was 100,000 (Huntingdon Research Centre, 1994)
I was working with r-12 and r-134a where the cardiac sensitizing has a much higher potential. :(
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/580560
Contrary to their reputation as being inert, aerosol fluoroalkane propellant gases (Freons) are rapidly acting and potent cardiac toxins. This discovery, first made in mice, has been confirmed during adequate oxygenation, either in vitro or in vivo, in rats, cats, dogs, monkeys, and man. This brief review demonstrates that propellant gases are toxic to the mouse heart, enter the blood after inhalation, and, despite adequate oxygenation, quickly cause ventricular tachyarrhythmias in monkeys and lower arterial pressure and peripheral resistance in several species, and are directly toxic to ventricular myocardium, profoundly depressing its contractility in all species studied, including man. Ventricular tachyarrhythmias, bradyarrhythmias, acute heart failure, arterial hypotension, and asphyxia may cause sudden death in youths who deliberately inhale aerosol propellants. The possibility that these gases are harmful, acutely or chronically, to frequent aerosol users requires further study.
The fluoroalkane gases used to propel aerosols were toxic to the hearts of 34 mice, sensitizing them to asphyxiainduced sinus bradycardia, atrioventricular block, and T-waue depression. Cardiac sensitization was rapid, long-lasting, and lethal. It also occurred in rats and dogs. The propellants are postulated to possess a spectrum of cardiotoxic effects capable, in various species, of causing bradyarrhythmias, tachyarrhythmias, or myocardial depression. In humans the cardiac toxicity of aerosol propellants, particularly during asphyxia, may be a cause of sudden death in youths who "turn on" by inhaling propellants and in patients with asthma who make excessive use of bronchodilator aerosols. To a degree presently unknown, cardiac toxicity, including arrhythmias, due to propellant inhalation may be a potential hazard to frequent users of pressurized aerosol dispensers.
Im not a chemist so keeping track of all these different types is a challenge lmao.
But whatever they use as a aerosol is likely going to be of this class of chemicals.
Prolly doing a favor for grandma honestly, going to suck switching for sure, but prolly worth it in the end.
By the way they have known about this for a hundred years, and WCB is going to claim they dont know any of it. Yeah whatever, bunch of shit head criminals.
https://www.sciencedirect.com/science/article/abs/pii/S0273230003000722
An increased sensitivity of the heart to endogenous epinephrine (adrenaline), a phenomenon referred to as cardiac sensitization, has long been recognized as a risk during exposure to hydrocarbons, principally halogenated hydrocarbons. Cardiac sensitization, which can result in serious arrhythmia and death, requires a certain critical blood level of both the sensitizing agent and epinephrine.
In the early 1900s, Levy and Lewis (1911) reported that cats lightly anesthetized with chloroform were unexpectedly sensitive to injected epinephrine. In these studies, the investigators administered chloroform at 0.5 or 2% in air followed by a bolus intravenous injection of epinephrine (up to 65 μg total dose). The authors described the electrocardiographic (ECG) pattern as “heterogenetic,” short pauses in heart rate followed by tachycardia. Continued administration of chloroform ultimately resulted in ventricular fibrillation.
Many halogenated and non-halogenated hydrocarbons do possess the ability to sensitize the myocardium to produce cardiac arrhythmia alone or in combination with injected epinephrine.
ARCA and WCB NOVA SCOTIA, are ABSOLUTLY CRIMINALS. 1000 FUCKING PERCENT.
Generally, high concentrations of agent, ranging from 0.5 to 90% in air, are required to produce cardiac sensitization and subsequent arrhythmias.
LMAO, I got wcb on phone saying they dont need to test teh air basically because freon cant cause irregular heartbeats.
So i have no idea how much I was being exposed to. Or what the current operator is being exposed too. Hope he dont have a family history of irregular heart rhythms too. No one helped me, no one cared. So I guess I really dont give a shit if they kill someone else.
Proably saving a few lives by not using the aerosol. But its kinda silly to use aerosol's anyway since they do eat up the ozone, and we do kinda need that.
But again, shocked me to find out they still use refrigerant in those ventolin brand puffers.
VENTOLIN HFA is a pressurized metered-dose aerosol unit fitted with a counter. VENTOLIN HFA is intended for oral inhalation only. Each unit contains a microcrystalline suspension of albuterol sulfate in propellant HFA-134a (1,1,1,2-tetrafluoroethane). It contains no other excipients.
R-134a and HFC-134a share the same chemical formula, C2H2F4, however, they have slightly different molecular structures. In contrast to R-134a, which is a chlorofluorocarbon (CFC), HFC-134a is a hydrofluorocarbon (HFC). The main difference is that CFCs include chlorine, which contributes to ozone depletion.
They still have this cardiac sensitizing potential though.
Five minutes later, they were exposed to the test substance for a total of approximately 10 minutes. After the first five minutes of exposure, each dog received a challenge injection of epinephrine. During the next five minutes of exposure, the dogs were monitored for the development of a cardiac arrhythmia. There were no arrhythmias at 75,000 ppm, and two of the 6 dogs displayed multifocal ventricular ectopic activity lasting approximately 2 seconds followed by several ectopic beats at 100,000 ppm. Under the conditions of this study, the no-observed-adverseeffect level (NOAEL) for cardiac sensitization was 75,000 ppm and the lowest-observed-adverse-effect level (LOAEL) was 100,000 (Huntingdon Research Centre, 1994)
I was working with r-12 and r-134a where the cardiac sensitizing has a much higher potential. :(
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/580560
Contrary to their reputation as being inert, aerosol fluoroalkane propellant gases (Freons) are rapidly acting and potent cardiac toxins. This discovery, first made in mice, has been confirmed during adequate oxygenation, either in vitro or in vivo, in rats, cats, dogs, monkeys, and man. This brief review demonstrates that propellant gases are toxic to the mouse heart, enter the blood after inhalation, and, despite adequate oxygenation, quickly cause ventricular tachyarrhythmias in monkeys and lower arterial pressure and peripheral resistance in several species, and are directly toxic to ventricular myocardium, profoundly depressing its contractility in all species studied, including man. Ventricular tachyarrhythmias, bradyarrhythmias, acute heart failure, arterial hypotension, and asphyxia may cause sudden death in youths who deliberately inhale aerosol propellants. The possibility that these gases are harmful, acutely or chronically, to frequent aerosol users requires further study.
The fluoroalkane gases used to propel aerosols were toxic to the hearts of 34 mice, sensitizing them to asphyxiainduced sinus bradycardia, atrioventricular block, and T-waue depression. Cardiac sensitization was rapid, long-lasting, and lethal. It also occurred in rats and dogs. The propellants are postulated to possess a spectrum of cardiotoxic effects capable, in various species, of causing bradyarrhythmias, tachyarrhythmias, or myocardial depression. In humans the cardiac toxicity of aerosol propellants, particularly during asphyxia, may be a cause of sudden death in youths who "turn on" by inhaling propellants and in patients with asthma who make excessive use of bronchodilator aerosols. To a degree presently unknown, cardiac toxicity, including arrhythmias, due to propellant inhalation may be a potential hazard to frequent users of pressurized aerosol dispensers.
Im not a chemist so keeping track of all these different types is a challenge lmao.
But whatever they use as a aerosol is likely going to be of this class of chemicals.
Prolly doing a favor for grandma honestly, going to suck switching for sure, but prolly worth it in the end.
By the way they have known about this for a hundred years, and WCB is going to claim they dont know any of it. Yeah whatever, bunch of shit head criminals.
https://www.sciencedirect.com/science/article/abs/pii/S0273230003000722
An increased sensitivity of the heart to endogenous epinephrine (adrenaline), a phenomenon referred to as cardiac sensitization, has long been recognized as a risk during exposure to hydrocarbons, principally halogenated hydrocarbons. Cardiac sensitization, which can result in serious arrhythmia and death, requires a certain critical blood level of both the sensitizing agent and epinephrine.
In the early 1900s, Levy and Lewis (1911) reported that cats lightly anesthetized with chloroform were unexpectedly sensitive to injected epinephrine. In these studies, the investigators administered chloroform at 0.5 or 2% in air followed by a bolus intravenous injection of epinephrine (up to 65 μg total dose). The authors described the electrocardiographic (ECG) pattern as “heterogenetic,” short pauses in heart rate followed by tachycardia. Continued administration of chloroform ultimately resulted in ventricular fibrillation.
Many halogenated and non-halogenated hydrocarbons do possess the ability to sensitize the myocardium to produce cardiac arrhythmia alone or in combination with injected epinephrine.
ARCA and WCB NOVA SCOTIA, are ABSOLUTLY CRIMINALS. 1000 FUCKING PERCENT.
Generally, high concentrations of agent, ranging from 0.5 to 90% in air, are required to produce cardiac sensitization and subsequent arrhythmias.
LMAO, I got wcb on phone saying they dont need to test teh air basically because freon cant cause irregular heartbeats.
So i have no idea how much I was being exposed to. Or what the current operator is being exposed too. Hope he dont have a family history of irregular heart rhythms too. No one helped me, no one cared. So I guess I really dont give a shit if they kill someone else.
Proably saving a few lives by not using the aerosol. But its kinda silly to use aerosol's anyway since they do eat up the ozone, and we do kinda need that.
But again, shocked me to find out they still use refrigerant in those ventolin brand puffers.
VENTOLIN HFA is a pressurized metered-dose aerosol unit fitted with a counter. VENTOLIN HFA is intended for oral inhalation only. Each unit contains a microcrystalline suspension of albuterol sulfate in propellant HFA-134a (1,1,1,2-tetrafluoroethane). It contains no other excipients.
R-134a and HFC-134a share the same chemical formula, C2H2F4, however, they have slightly different molecular structures. In contrast to R-134a, which is a chlorofluorocarbon (CFC), HFC-134a is a hydrofluorocarbon (HFC). The main difference is that CFCs include chlorine, which contributes to ozone depletion.
They still have this cardiac sensitizing potential though.
Five minutes later, they were exposed to the test substance for a total of approximately 10 minutes. After the first five minutes of exposure, each dog received a challenge injection of epinephrine. During the next five minutes of exposure, the dogs were monitored for the development of a cardiac arrhythmia. There were no arrhythmias at 75,000 ppm, and two of the 6 dogs displayed multifocal ventricular ectopic activity lasting approximately 2 seconds followed by several ectopic beats at 100,000 ppm. Under the conditions of this study, the no-observed-adverseeffect level (NOAEL) for cardiac sensitization was 75,000 ppm and the lowest-observed-adverse-effect level (LOAEL) was 100,000 (Huntingdon Research Centre, 1994)
I was working with r-12 and r-134a where the cardiac sensitizing has a much higher potential. :(
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/580560
Contrary to their reputation as being inert, aerosol fluoroalkane propellant gases (Freons) are rapidly acting and potent cardiac toxins. This discovery, first made in mice, has been confirmed during adequate oxygenation, either in vitro or in vivo, in rats, cats, dogs, monkeys, and man. This brief review demonstrates that propellant gases are toxic to the mouse heart, enter the blood after inhalation, and, despite adequate oxygenation, quickly cause ventricular tachyarrhythmias in monkeys and lower arterial pressure and peripheral resistance in several species, and are directly toxic to ventricular myocardium, profoundly depressing its contractility in all species studied, including man. Ventricular tachyarrhythmias, bradyarrhythmias, acute heart failure, arterial hypotension, and asphyxia may cause sudden death in youths who deliberately inhale aerosol propellants. The possibility that these gases are harmful, acutely or chronically, to frequent aerosol users requires further study.
The fluoroalkane gases used to propel aerosols were toxic to the hearts of 34 mice, sensitizing them to asphyxiainduced sinus bradycardia, atrioventricular block, and T-waue depression. Cardiac sensitization was rapid, long-lasting, and lethal. It also occurred in rats and dogs. The propellants are postulated to possess a spectrum of cardiotoxic effects capable, in various species, of causing bradyarrhythmias, tachyarrhythmias, or myocardial depression. In humans the cardiac toxicity of aerosol propellants, particularly during asphyxia, may be a cause of sudden death in youths who "turn on" by inhaling propellants and in patients with asthma who make excessive use of bronchodilator aerosols. To a degree presently unknown, cardiac toxicity, including arrhythmias, due to propellant inhalation may be a potential hazard to frequent users of pressurized aerosol dispensers.
Im not a chemist so keeping track of all these different types is a challenge lmao.
But whatever they use as a aerosol is likely going to be of this class of chemicals.
Prolly doing a favor for grandma honestly, going to suck switching for sure, but prolly worth it in the end.
By the way they have known about this for a hundred years, and WCB is going to claim they dont know any of it. Yeah whatever, bunch of shit head criminals.
https://www.sciencedirect.com/science/article/abs/pii/S0273230003000722
An increased sensitivity of the heart to endogenous epinephrine (adrenaline), a phenomenon referred to as cardiac sensitization, has long been recognized as a risk during exposure to hydrocarbons, principally halogenated hydrocarbons. Cardiac sensitization, which can result in serious arrhythmia and death, requires a certain critical blood level of both the sensitizing agent and epinephrine.
In the early 1900s, Levy and Lewis (1911) reported that cats lightly anesthetized with chloroform were unexpectedly sensitive to injected epinephrine. In these studies, the investigators administered chloroform at 0.5 or 2% in air followed by a bolus intravenous injection of epinephrine (up to 65 μg total dose). The authors described the electrocardiographic (ECG) pattern as “heterogenetic,” short pauses in heart rate followed by tachycardia. Continued administration of chloroform ultimately resulted in ventricular fibrillation.
Many halogenated and non-halogenated hydrocarbons do possess the ability to sensitize the myocardium to produce cardiac arrhythmia alone or in combination with injected epinephrine.
ARCA and WCB NOVA SCOTIA, are ABSOLUTLY CRIMINALS. 1000 FUCKING PERCENT.