just as a thought exercise, mrna degrades easily so they use lipid nanoparticles to help get the genetic material through the cell membrane into the cell. they use pegylated lipids or polyethylene glycol (PEG) to help with storage and as adjuvants. When the lipid nanoparticles come into contact with cells, they trick the cell and enter, then dispense the mrna.
If the lipid nanoparticles were lysed and broken and the mrna exposed before it made it into a cell, it should be degraded rapidly. There's some studies out there on lipases and lipozymes which are enzymes which break apart lipids. Another idea maybe if all other sites were filled with lipids already then binding sites might be blocked. Either would probably need to be at highest concentration near injection site, so easier to inject vs. taking systemically.
Some people have anti-PEG antibodies from past exposures to these from various sources. Not sure what happens when immune cells attack the PEG on the nanoparticle, or if the nanoparticle still enters the immune cells.
...
Safest option would be don't take it.
Second safest, take saline or something instead ;).
Someone else had a good writeup on pine leaves out there.
...
I agree with everyone else that now is the time to exercise things through legal and noncompliance actions primarily, though understand the point that cases vary.

just as a thought exercise, mrna degrades easily so they use lipid nanoparticles to help get the genetic material through the cell membrane into the cell. they use pegylated lipids or polyethylene glycol (PEG) to help with storage and as adjuvants. When the lipid nanoparticles come into contact with cells, they trick the cell and enter, then dispense the mrna.
If the lipid nanoparticles were lysed and broken and the mrna exposed before it made it into a cell, it should be degraded rapidly. There's some studies out there on lipases and lipozymes which are enzymes which break apart lipids. Maybe if all other sites were filled with lipids already then binding sites might be blocked. Either would probably need to be at highest concentration near injection site, so easier to inject vs. taking systemically.
Some people have anti-PEG antibodies from past exposures to these from various sources. Not sure what happens when immune cells attack the PEG on the nanoparticle, or if the nanoparticle still enters the immune cells.
...
Safest option would be don't take it.
Second safest, take saline or something instead ;).
Someone else had a good writeup on pine leaves out there.
...
I agree with everyone else that now is the time to exercise things through legal and noncompliance actions primarily, though understand the point that cases vary.