because i am smooth brain i am trying to understand

https://www.sciencedirect.com/science/article/pii/S1931312822005728

Viruses that replicate in the human respiratory mucosa without infecting systemically, including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other “common cold” viruses, cause significant mortality and morbidity and are important public health concerns. Because these viruses generally do not elicit complete and durable protective immunity by themselves, they have not to date been effectively controlled by licensed or experimental vaccines.

What is lord fauci trying to say about #SafeAndEffective?