I think this is over the target now. Smallpox, HIV, and COVID all cause essentially the same immunosenesence (immune system decline) pattern caused by systemic immune activation (IA) response —> immune inflammation. The vaccine causes a similar IA responses and thus the booster plan will essentially seem to accelerate immune aging.

Source: https://www.hindawi.com/journals/mi/2017/6825493/

/u/ghost_of_aswartz - fyi because I promised a post on this

/u/ghost_of_aswartz i think this is over the target now. Smallpox, HIV, and COVID all cause essentially the same immunosenesence (immune system decline) pattern.