From May 2019 Journal of Nanobiotechnology 17(1)
DOI:10.1186/s12951-019-0506-y
"Biochemical functionality of magnetic particles as nanosensors: how far away are we to implement them into clinical practice?" --May 2019
Start reading around the 100th citation mark.
"Nanoparticles, once present in the body, may target various systems. Here are effects of nanoparticles found on the circulatory system, where nanoparticles indirectly influence for example blood pressure [98]. Important to note when looking at the circulatory system is the fact that nanoparticles are engineered to influence the coagulation system of the blood [99]. At the same time, MNPs, designed for any other indication, may evoke an unwanted pro- or anticoagulant effect in the blood [100]."
"The reproductive system is another target of nanoparticles with possible detrimental effects. Upon in-vivo applications, nanoparticles may accumulate in reproductive organs [102, 103], where they have direct effects on germ cells with reduced cell count or activity in both, female and male germ cells [104, 105]. Furthermore, nanoparticles are able to alter or damage DNA in cells, which would be especially problematic in germ cells [106]. In a recent in-vitro study, uptake of coated SPIONs in granulosa cells was tested. It was found that depending on the coating, no or only low uptake and toxicity of SPIONs was observed [107].
Since it is now known that the vax spike protein enters cells and damages the DNA repair mechanism, we can see that the combination of that and the nanoparticle damage to DNA are a one-two punch that can easily induce cancer.
Submission Statement:
From May 2019 Journal of Nanobiotechnology 17(1) DOI:10.1186/s12951-019-0506-y
"Biochemical functionality of magnetic particles as nanosensors: how far away are we to implement them into clinical practice?" --May 2019
Start reading around the 100th citation mark.
"Nanoparticles, once present in the body, may target various systems. Here are effects of nanoparticles found on the circulatory system, where nanoparticles indirectly influence for example blood pressure [98]. Important to note when looking at the circulatory system is the fact that nanoparticles are engineered to influence the coagulation system of the blood [99]. At the same time, MNPs, designed for any other indication, may evoke an unwanted pro- or anticoagulant effect in the blood [100]."
"The reproductive system is another target of nanoparticles with possible detrimental effects. Upon in-vivo applications, nanoparticles may accumulate in reproductive organs [102, 103], where they have direct effects on germ cells with reduced cell count or activity in both, female and male germ cells [104, 105]. Furthermore, nanoparticles are able to alter or damage DNA in cells, which would be especially problematic in germ cells [106]. In a recent in-vitro study, uptake of coated SPIONs in granulosa cells was tested. It was found that depending on the coating, no or only low uptake and toxicity of SPIONs was observed [107].
[credit to David Botha]
Since it is now known that the vax spike protein enters cells and damages the DNA repair mechanism, we can see that the combination of that and the nanoparticle damage to DNA are a one-two punch that can easily induce cancer.