In 2022, a whistleblower revealed that a landmark 2006 paper published in Nature was full of falsified data. This paper supported the amyloid hypothesis Alzheimer's; $1.6 billion of wasted NIH funding resulted in a failed attempt to build upon a fake line of inquiry.
https://www.simonandschuster.com/books/Doctored/Charles-Piller/9781668031254
I need to start keeping a list of these for immediate reference.