A person who is a friend of or loves the way this world operates, with the desires of the flesh and the desires of the eyes and pride of life being its primary cogwheels, is a person who cannot also focus on the Father's will. A person who loves and is focused on the material things of this world cannot also love and serve God. Therefore, those of us who truly believe, must come out of the world renouncing our ungodliness and worldly passions, and place our devotion, love, and focus securely in God and His will. The world is passing away along with its desires but rejoice and be exceedingly glad: for whoever does the will of God abides forever.
We must be transformed by the renewal of our minds through the Spirit who is from God, and live self-controlled, upright, and godly lives in the present age, waiting for our blessed hope, the appearing of the glory of our great God and Saviour Jesus Christ, who gave Himself for us to redeem us from all lawlessness and to purify for himself a people for his own possession who are zealous for good works. The world will hate us for this, but we are not to be discouraged. Many walk as enemies of Christ. Their end is destruction, their god is their belly, and they glory in their shame, with minds set on earthly things. Our citizenship is in heaven, and from it we await a Saviour, the Lord Jesus Christ, who will transform our lowly body to be like His glorious body, by the power that enables Him even to subject all things to Himself.
It is against the flesh and our sinful nature, yes. However, you can be spiritually re-born my friend and given a new Spirit, the Holy Spirit. God can give you a new heart and His Holy Spirit, which will give you wisdom and revelation in the knowledge of Him, put His Laws on your heart and mind, guide you into all the truth, help you, and comfort you. By the blood of Jesus, sanctifying you and cleansing you of all unrighteousness—conforming you to His image.
But I say, walk by the Spirit, and you will not gratify the desires of the flesh. For the desires of the flesh are against the Spirit, and the desires of the Spirit are against the flesh, for these are opposed to each other, to keep you from doing the things you want to do. But if you are led by the Spirit, you are not under the law. Now the works of the flesh are evident: sexual immorality, impurity, sensuality, idolatry, sorcery, enmity, strife, jealousy, fits of anger, rivalries, dissensions, divisions, envy, drunkenness, orgies, and things like these. I warn you, as I warned you before, that those who do such things will not inherit the kingdom of God. But the fruit of the Spirit is love, joy, peace, patience, kindness, goodness, faithfulness, gentleness, self-control; against such things there is no law. And those who belong to Christ Jesus have crucified the flesh with its passions and desires. If we live by the Spirit, let us also keep in step with the Spirit. Let us not become conceited, provoking one another, envying one another. (Galatians 5:16-26 ESV)
Now there was a man of the Pharisees named Nicodemus, a ruler of the Jews. This man came to Jesus by night and said to him, "Rabbi, we know that you are a teacher come from God, for no one can do these signs that you do unless God is with him." Jesus answered him, "Truly, truly, I say to you, unless one is born again he cannot see the kingdom of God." Nicodemus said to him, "How can a man be born when he is old? Can he enter a second time into his mother's womb and be born?" Jesus answered, "Truly, truly, I say to you, unless one is born of water and the Spirit, he cannot enter the kingdom of God. That which is born of the flesh is flesh, and that which is born of the Spirit is spirit. Do not marvel that I said to you, 'You must be born again.' The wind blows where it wishes, and you hear its sound, but you do not know where it comes from or where it goes. So it is with everyone who is born of the Spirit." (John 3:1-8 ESV)
God is spirit, and those who worship him must worship in spirit and truth." (John 4:24 ESV)