A lot of sci fi and even paranoid government programs (eg. COG protocols), explore the ideas of humanity hiding out in underground bunkers to survive the self induced apocalypse de jour. How long could something such as this actually last before everyone perishes? (My thoughts in comments).
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That's very specific. What makes you suggest such a specific number?
That's the length of time Biosphere 2's first mission lasted. Link is to the wikipedia article.