So many open questions, some that come to mind:

1. the “problem” of consciousness (aka the source and mechanism)

2. the observer “problem” of quantum mechanics

3. the “dark matter” “problem”

4. the “dark energy”/“zero-point energy” “problem”

5. hell, going on 100 years now and we still don’t have a scale-invariant theory of the universe (quantum and macro systems don’t reconcile)

(Edit) 6) the finely tuned universe “problem” https://en.m.wikipedia.org/wiki/Fine-tuned_universe

The fact that people are so confident in their error is the worst part. “Safe and effective” - until their priests educate them otherwise