It doesn't settle. There are many lipid based meds on the market. They dont come out of suspension. If it does you dont use it. Even it if did you shake the vial to mix it before drawing it up. And If it did settle (in a reconstitution situation) and you didn't inject it all you have an unknown mixture. Its insane. This is coming for a medical professional. I know many who give the injections are not pros. But that is no excuse. That was on propose.