No. At least not the current jabs.

Were I an evil mastermind with unlimited resources, I would create a swine-flu esq nothingburger and purposefully distort it in the media so that the NPCs believe it is the next black plague. I would then mass-distribute a vaccine that is horribly ineffective by vaccination standards so that the NPCs take them, but the dissidents don't. After enough NPCs took the shot, I would release an actual deadly plague that (plot twist) the aforementioned vaccines are actually effective against. I would also stop production of the shot at this point. Now the NPCs are all already safe, and most of the dissidents die off.

Depopulation: Achieved

Dissidents: holocausted

Blame: averted

Power: secured