"One of the heads of the beast appeared to be mortally wounded. But the mortal wound was healed, and the whole world marveled and followed the beast. They worshiped the dragon who had given authority to the beast, and they worshiped the beast, saying, “Who is like the beast, and who can wage war against it?” " -- Rev 13:3

Is a prion disease a mortal head wound? Well prion diseases are considered to be "always fatal" according to the CDC, so that would be a mortal head wound just at the molecular level. https://www.cdc.gov/prions/index.html

And as everyone here surely knows there is serious speculation about the spike protein AND mRNA from these injection being prions or prion catalysts themselves.
http://hmi-us.com/publications/sars-cov-2-prion-like-domains-in-spike-proteins-enable-higher-affinity-to-ace2.html https://greatgameindia.com/mrna-vaccines-degenerate-brain-prion/

So assuming in the coming years we see an explosion of prion related illnesses, we could also expect this "wound" to be healed using new beast technology. As you can see in these references, research has already been underway using CRISPR gene editing technology to address Alzheimer's disease and other protein misfolding diseases.
https://pubmed.ncbi.nlm.nih.gov/32854251/ https://www.qps.com/2021/08/22/clinical-trial-shows-in-vivo-crispr-cas9-therapy-effective-against-rare-disease/

So after this happens the "beast" is genetically modified and manages to survive using this technology. Continuing on we read:

"Then the beast was permitted to wage war against the saints and to conquer them, and it was given authority over every tribe and people and tongue and nation" -- Rev 13:7.

It may be that this genetically modified army will be able to conquer the world. They may use other technology such as space weaponry which brings "fire down from heaven" (Rev 13:13). Some believe globalists have been practicing with these weapons on California. There has also been a joke meme going around mocking conspiracy theorists about "jewish space lasers". Sometimes tptb mock what they know is coming to deceive their followers.

On the same page comes the "Mark of the Beast" itself

"And the second beast required all people small and great, rich and poor, free and slave, to receive a mark on their right hand or on their forehead" Rev 13:16

This is clearly being foreshadowed as nations enact passports to Buy and Sell. So the idea of needing something to Buy and Sell is being set up in the public's mind.

https://biblehub.com/bsb/revelation/13.htm

This is all just a theory. For all I know the mark of the beast will be coming next, and the "head wound" being referred to is something that already was healed and is more metaphorical. But I can say this: I will treat this vaccine and all future "therapies" pushed on us by the beast system as the mark itself. I will not comply with any of it even unto death so help me God.